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Why Is Lupron Depot Used for Uterine Fibroids?

Uterine fibroids are noncancerous growths of the uterus. They are relatively common in women of childbearing age and normally don't cause any problems. However, some women may experience symptoms from fibroids, such as:
  • Heavy or long periods
  • Pelvic pain or "fullness"
  • Frequent urination or difficulty emptying the bladder
  • Constipation.
Most of the time, treatment for uterine fibroids depends on the woman's preferences. Because fibroids are not cancerous and may not cause symptoms, many women choose not to have any treatment at all. If fibroids are causing pain or anemia due to heavy bleeding, some form of treatment may be needed. In these cases, treatment options can include surgery or medications.
Lupron Depot is used in combination with iron before fibroid surgery to reduce anemia from heavy bleeding. Your healthcare provider may choose to give you iron alone for one month before giving you Lupron Depot. If your anemia improves with iron treatment, you may not need to use Lupron Depot. This medication should not be used for longer than three months in women with fibroids.

Lupron Depot Uses for Central Precocious Puberty

Puberty is the process that occurs when the body starts to change from a child into an adult. Children with central precocious puberty (also simply called precocious puberty) begin puberty at a very early age. Precocious puberty is usually defined as puberty that starts before age eight in girls or age nine in boys.
Precocious puberty can be categorized as central or peripheral. Peripheral precocious puberty is caused by the release of testosterone or estrogen into the body. The testosterone (in boys) or estrogen (in girls) triggers physical changes associated with puberty. Peripheral precocious puberty may be due to problems with the testicles, ovaries, or certain glands in the body, such as the pituitary or adrenal gland.
In contrast, central precocious puberty occurs when puberty begins earlier than normal but undergoes the expected pattern. Gonadotropin-releasing hormone (GnRH) is involved in central precocious puberty. Most of the time, the underlying cause of central precocious puberty is unknown and often there is no underlying medical problem at all.
Children with precocious puberty start to experience the physical changes of puberty at an early age. These may include:
  • Breast growth and menstruation in girls
  • Voice changes and enlarged testicles and penis in boys
  • Hair growth (pubic, underarm, and facial hair)
  • Growth spurt.
Precocious puberty can cause psychological problems in children. Children may feel self-conscious about the changes that are occurring in their bodies because their peers are not experiencing the same changes. Children may be expected to act older than they are because they look older, which can be stressful and confusing for the child.
If left untreated, precocious puberty can also cause growth problems. Children with this condition may experience a growth spurt, making them taller than their peers initially. However, the bones grow and mature too quickly and stop growing earlier than normal. Because there is less time for later bone growth and development, children may not reach their full height potential as adults.
The goal of treatment for precocious puberty is to temporarily stop the early puberty and prevent further changes in the body until the appropriate time. Lupron Depot can reduce the amount of testosterone (in boys) and estrogen (in girls) produced by the body, which can delay puberty and slow down early bone growth.
Lupron Depot should only be prescribed for children who have a confirmed diagnosis of central precocious puberty. If something else is causing your child's early signs of puberty, other treatment may be needed. Your child's healthcare provider will do a variety of tests before diagnosing your child.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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