Prostate Cancer Home > Lupron Depot Dosage

In general, people receive their dose of Lupron Depot at a healthcare provider's office, although you can administer the injection yourself. The amount your healthcare provider prescribes will depend on a few different factors, including the condition being treated. In addition, you may receive this medication monthly, every three months, or every four months. The individual forms of Lupron Depot are not interchangeable.

An Introduction to Dosing With Lupron Depot

The Lupron Depot® (leuprolide acetate depot) dosage your healthcare provider recommends will vary, depending on a number of factors, including:
  • The reason you are using the medication
  • Your weight (in children)
  • How you respond to it.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Lupron Depot Dosage for Advanced Prostate Cancer

The standard dose of Lupron Depot in advanced prostate cancer depends on the specific product used. This medication is available in a one-month, three-month, and four-month form for advanced prostate cancer treatment. The usual dosing options for these forms are as follows:
  • Lupron Depot 7.5 mg once monthly
  • Lupron Depot-3 Month 22.5 mg once every three months (every 84 days)
  • Lupron Depot-4 Month 30 mg once every four months (every 16 weeks)
  • Lupron Depot-6 Month 45 mg once every six months (every 24 weeks).


The individual Lupron Depot dosage forms are not interchangeable. This means that, for example, 7.5 mg of Lupron Depot-3 Month is not equivalent to 7.5 mg of Lupron Depot monthly, regardless of how often the medications are given.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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