Prostate Cancer Home > Fentanyl Nasal Spray Side Effects

A few of the common side effects of fentanyl nasal spray include dizziness, nausea, and vomiting. Although these reactions typically require little or no treatment, potentially serious problems are also possible. If you experience more serious problems with this pain medicine, such as extreme drowsiness, severe constipation, or hallucinations, contact your healthcare provider right away.

An Introduction to Side Effects of Fentanyl Nasal Spray

Just like any medicine, fentanyl nasal spray (Lazanda®) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with fentanyl nasal spray. Your healthcare provider can discuss a more complete list with you.)

Serious Fentanyl Nasal Spray Side Effects

Some fentanyl nasal spray side effects are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • The urge to use more fentanyl nasal spray than prescribed or for a nonmedical purpose (see Lazanda Abuse)
  • Problems breathing, including reduced, shallow, slow, or irregular breaths
  • A slow heart rate (bradycardia)
  • Decreased blood pressure (hypotension), which could cause you to feel faint or lightheaded, especially when sitting or standing up
  • Extreme drowsiness
  • Chest pain that worsens with deep breathing or coughing
  • Feeling faint, dizzy, or confused
  • Severe constipation
  • Unusual changes in behavior or mood, including depression, hostility, agitation, or anxiety
  • Hallucinations (seeing or hearing things that are not really there)
  • Swelling, pain, or tenderness in one or both legs
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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