Prostate Cancer Home > Drug Interactions With Fentanyl Nasal Spray

Medications That Cause Drowsiness
Fentanyl nasal spray causes significant drowsiness. Taking other medications that cause drowsiness while using fentanyl nasal spray may lead to serious side effects, such as extreme sedation, confusion, and serious breathing problems. Check with your healthcare provider before using fentanyl nasal spray with other medications that can cause drowsiness.
Monoamine Oxidase Inhibitors (MAOIs)
Combining fentanyl nasal spray with an MAOI may cause a serious reaction known as serotonin syndrome. It can also lead to low blood pressure. Do not use fentanyl nasal spray if you have taken an MAOI within the past 14 days.
Nasal Decongestants
Nasal sprays that are used to treat congestion may interfere with the absorption of fentanyl nasal spray through the lining of the nose, potentially making it less effective. Talk to your healthcare provider about this potential reaction before using a nasal decongestant with fentanyl nasal spray.

Final Thoughts

It is possible that not all fentanyl nasal spray drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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