Zytiga Uses

How Does This Medicine Work?

Testosterone stimulates the growth of prostate cancer cells. Zytiga works by inhibiting an enzyme in the body called cytochrome P450 17 (CYP17). This enzyme helps make testosterone. By blocking CYP17 activity, Zytiga decreases the amount of testosterone produced in the body.
 
The majority of testosterone in the body is produced by the testes. However, some testosterone is also made by the adrenal glands and in the prostate cancer cells. Zytiga decreases testosterone made in the cancer cells and the adrenal gland. Therefore, this drug may work in prostate cancer that has been resistant to other medical or surgical treatments that only worked to decrease testosterone made by the testes.
 

Is It Safe for Children?

Zytiga is not approved for people younger than 18 years of age, as it has not been adequately studied in this age group.
 

Can Older Adults Use Zytiga?

The majority of people who participated in Zytiga clinical trials were 65 years of age and older. There were no observed differences in the safety or effectiveness of Zytiga in older and younger age groups.
 

Off-Label Uses for Zytiga

On occasion, healthcare providers may recommend this medicine for something other than its approved use. This is known as an "off-label" use. The use of Zytiga in men who have not previously received chemotherapy with docetaxel would be considered an off-label use.
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Zytiga Medication Information

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