Zytiga Drug Interactions
Zytiga Drug Interactions ExplainedThe following sections explain in detail the potentially negative interactions that can occur when Zytiga is combined with any of the drugs listed above.
Zytiga may increase blood levels of atomoxetine, potentially increasing the risk for side effects. If you take these medicines together, your healthcare provider may need to adjust your atomoxetine dose, especially when you first start or stop taking Zytiga.
Zytiga can increase blood levels of carvedilol. If you take these medicines together, your healthcare provider will likely monitor your blood pressure and heart rate, and adjust your carvedilol dose if needed.
Zytiga can make clopidogrel less effective. In general, it is not recommended to use these medicines together.
Zytiga can make codeine less effective at controlling pain. If you are taking Zytiga and need a pain reliever, your healthcare provider might consider giving you a pain medicine that does not contain codeine.
Zytiga can increase colchicine blood levels, increasing your risk for potentially serious colchicine side effects. If you take these medications together, your healthcare provider may give you a lower colchicine dose. He or she will also likely monitor you closely for colchicine toxicity.
CYP 3A4 Inducer Medications
The liver breaks down Zytiga using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining Zytiga with one of these CYP 3A4 inducers may decrease the level of Zytiga in your bloodstream, making it less effective. Your healthcare provider may need to monitor you more closely to make sure Zytiga is working if you take it with a CYP 3A4 inducer.
Your healthcare provider may recommend taking twice as much Zytiga (split into two doses per day) while you are taking certain strong CYP 3A4 inducers.