For treating late-stage prostate cancer with Zytiga, the standard dose is usually 1000 mg once a day, along with 5 mg of prednisone twice daily. However, if you have liver problems, you will probably take less Zytiga. Make sure to take your Zytiga tablets on an empty stomach; however, the prednisone must be taken with food.
An Introduction to Dosing With ZytigaThe dose of Zytiga™ (abiraterone acetate) your healthcare provider recommends may vary, depending on whether you have liver problems or develop liver problems during treatment. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
What Is the Zytiga Dosage for Prostate Cancer?The standard Zytiga dose for late-stage prostate cancer is 1000 mg once a day. Zytiga is given in combination with prednisone 5 mg twice a day.
The standard dosage of Zytiga for late-stage prostate cancer in people with moderate liver impairment is Zytiga 250 mg once a day. This medicine should not be used in people with severe liver impairment.
If liver damage occurs during treatment with this medication, treatment should be temporarily stopped until liver function tests return to normal. At that time, Zytiga may be restarted at a dosage of 750 mg once a day. If liver damage recurs, the drug should be stopped until liver function improves, and restarted at a dosage of 500 mg once a day. Zytiga should be discontinued permanently if liver damage occurs at the 500-mg dose.
While once-a-day dosing is generally recommended, your doctor might recommend twice-a-day dosing -- essentially doubling your normal total daily amount -- if you need to take certain other medications that tend to lower blood levels of Zytiga (see Zytiga Drug Interactions). If you stop taking the other interacting medication, your doctor should put you back on a normal, once-a-day Zytiga dosage.