Zoladex Uses

Zoladex Use for Endometrial Thinning

Dysfunctional uterine bleeding (also called abnormal uterine bleeding) is a medical term that describes abnormal vaginal bleeding due to an imbalance in hormone levels. Women with dysfunctional uterine bleeding may experience heavy or longer-than-normal periods. They may also have bleeding or spotting between periods.
Endometrial ablation is a procedure that is used to treat dysfunctional uterine bleeding. It destroys a thin layer of the endometrium, which reduces or stops uterine bleeding. Unlike a hysterectomy, the uterus (or womb) is not removed during endometrial ablation. However, pregnancy is not likely after the procedure. Therefore, it is not recommended for women who wish to become pregnant.
Endometrial ablation works well in most cases. The lower strength of Zoladex is approved to thin the lining of the uterus before this procedure and may help improve the success rate.

How Does This Medicine Work?

Zoladex belongs to a group of drugs called gonadotropin-releasing hormone (GnRH) agonists. GnRH is a hormone found naturally in the body. It controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland (a tiny gland located beneath the brain). LH and FSH stimulate the production of testosterone in the testes and estrogen in the ovaries.
Zoladex acts like GnRH, stimulating the production of LH and FSH. However, after several weeks, Zoladex overstimulates the pituitary gland and it stops making these hormones. As a result, levels of testosterone and estrogen are decreased. This decrease is responsible for Zoladex's therapeutic effects.
Zoladex comes as a tiny implant that is injected beneath the skin of the abdomen (stomach). The implant slowly releases the medication as it dissolves over a period of 4 to 12 weeks, depending on the strength of the implant being used.
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Zoladex Drug Information

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