Zoladex Side Effects

In clinical trials, some of the most commonly reported side effects of Zoladex included hot flushes, headaches, and mood changes. Other common reactions included decreased sex drive, sweating, and fluid retention. While most of these problems are typically easy to treat, contact your healthcare provider immediately if you develop vision problems, chest pain, or any other potentially serious side effect.

An Introduction to Zoladex Side Effects

Just like any medicine, Zoladex® (goserelin acetate implant) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with Zoladex. Your healthcare provider can discuss a more complete list with you.)
 

Common Side Effects of Zoladex

Zoladex has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people who received Zoladex were carefully documented and compared to those that occurred in another group of people who received a different treatment or a placebo (an implant that did not contain any active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the other groups.
 
In these studies, common Zoladex side effects included:
 
  • Hot flushes -- in up to 96 percent of people
  • Headaches -- up to 75 percent
  • Vaginal irritation, itching, or discharge -- up to 75 percent
  • Decreased libido (sex drive) -- up to 61 percent
  • Mood changes -- up to 60 percent
  • Flushing (sudden redness of the face and neck) -- up to 57 percent
  • Sweating -- up to 45 percent
  • Acne -- up to 42 percent
  • Diarrhea -- up to 40 percent
  • Breast atrophy -- up to 33 percent
  • Flaky skin (dandruff) -- up to 26 percent
  • Fluid retention (edema) of the legs, ankles, and feet -- up to 21 percent
  • Decreased erections -- up to 18 percent.
 
Other common reactions, occurring in 1 to 18 percent of people, included but were not limited to:
 
  • Breast swelling, pain, or tenderness
  • Body pain, including pelvic, back, abdominal (stomach), muscle, and joint pain
  • Infections, such as urinary tract infections (UTIs) and respiratory tract infections
  • Pain during sexual intercourse
  • Urinary tract symptoms, such as feeling the need to urinate with urgency or more often than normal
  • Increased libido (sex drive)
  • Weakness and fatigue
  • Insomnia
  • Nausea and vomiting
  • Skin rash
  • Excessive or abnormal hair growth in women
  • Increased blood pressure (hypertension)
  • Increased or decreased appetite
  • Respiratory problems, such as coughing or breathing difficulty
  • Flu-like symptoms, including fever and chills
  • Dizziness
  • Injection site reactions
  • Hair loss (alopecia)
  • Nervousness
  • Painful menstrual periods
  • Constipation
  • Voice changes in women
  • Itching
  • Increased muscle tension
  • General feeling of discomfort
  • Dry mouth, eyes, or skin
  • Heartburn or indigestion
  • Bruising
  • Numbness, tingling, or pricking sensations of the skin
  • Drowsiness
  • Nosebleeds
  • Irregular or painful menstrual periods.
 
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