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Trelstar
If you are a man with advanced prostate cancer, your healthcare provider may recommend a drug called Trelstar. This injectable medicine works by reducing testosterone levels in the body. Depending on what your healthcare provider recommends, the medication may be given once every one, three, or six months. Possible side effects include erectile dysfunction, hot flashes, and pain.
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Trelstar® (triptorelin pamoate) is a prescription medication approved for the management of advanced prostate cancer. It is a long-acting injectable medicine given every one, three, or six months. Trelstar slows the growth of prostate cancer cells and eases symptoms of the disease. However, it is not a prostate cancer cure.
(Click Trelstar Uses for more information on this topic, including possible off-label uses.)
Trelstar is manufactured by Debio RP for Watson Pharma, Inc.
Trelstar is a synthetic (manufactured) version of gonadotropin-releasing hormone (GnRH), a hormone found naturally in the body. GnRH controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland (a tiny gland located beneath the brain). LH and FSH stimulate production of testosterone in the testes.
Trelstar works by overstimulating the pituitary gland so that it stops making LH and FSH. As a result, the testes stop making testosterone. Prostate cancer cells grow in response to testosterone. By reducing levels, Trelstar slows the growth of prostate cancer.
Trelstar injection is specially formulated so that the medicine is slowly released into the bloodstream. The monthly injection slowly releases the medicine over a four-week period. The three-month injection slowly releases the medicine over a 12-week period. The six-month injection slowly releases medicine over a 24-week period.
Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD