Supprelin
® LA (
histrelin implant) is a prescription medication approved for use in children who have a condition called central precocious puberty. Children with this condition start puberty (when the body changes from a child's body into an adult body) too early.
Supprelin LA is a small, flexible implant that, once inserted under the skin, releases medicine into the body for a full year. It belongs to a group of medicines called gonadotropin-releasing hormone (GnRH) agonists, also known as luteinizing hormone-releasing hormone (LH-RH) agonists. Supprelin LA and other GnRH agonists are used to stop early puberty until the child is older.
Who Makes This Medication?
Supprelin LA is manufactured by Endo Pharmaceuticals Solutions, Inc.
How Does Supprelin LA Work?
Supprelin LA is a synthetic (manufactured) form of gonadotropin-releasing hormone (GnRH), a naturally occurring hormone in the body. It controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland (a tiny gland located beneath the brain). LH and FSH stimulate the production of testosterone in the testes and estrogen in the ovaries.
Supprelin LA works by overstimulating the pituitary gland. When overstimulated, the pituitary does not make as much LH and FSH. As a result, the testes stop making testosterone and the ovaries stop making estrogen. This causes testosterone (in boys) and estrogen (in girls) levels to decrease, temporarily stopping puberty.
The Supprelin LA implant is specially formulated to slowly release medicine into the body over a 12-month period. This allows for once-a-year dosing.
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