Supprelin LA Uses
Supprelin LA can temporarily stop puberty that has started too early in boys or girls. This prescription medicine works by decreasing the amount of testosterone (in boys) and estrogen (in girls). It is approved for use in children as young as two years old. There are currently no off-label, or unapproved, uses for Supprelin LA.
What Is Supprelin LA Used For?Supprelin® LA (histrelin implant) is a prescription medication approved to treat central precocious puberty (CPP) in children who are at least two years old. It comes as a small, flexible implant that is inserted just beneath the skin on the upper arm. The implant slowly releases medication into the body for an entire year, before it is removed and (if treatment is to continue) replaced.
CPP is a condition in which puberty (the period of sexual maturation) starts earlier than normal -- before age eight in girls and age nine in boys. Girls may start to have breast development and, in some girls, menstrual periods. Boys may experience growth of the penis and testicles, as well as voice changes. Other usual puberty changes can also occur, including:
- Pubic hair growth
- Underarm and facial hair growth
- A sudden growth spurt.
If left untreated, the sudden growth spurt from CPP may lead to later growth problems. The bones grow and mature too quickly, and stop growing earlier than normal. Because there is less time for later bone growth and development, children may not reach their expected adult height.
The goal of treatment is to temporarily stop puberty and prevent further changes in the body until the appropriate time. Medications like Supprelin LA can be used to delay puberty until a more appropriate age. Treatment will normally end before age 11 in girls and age 12 in boys, to allow for normal sexual maturation.
Before your child is started on such a medication, his or her healthcare provider will do a variety of tests to look for underlying causes of CPP. In most cases, the underlying cause is unknown. If, however, your child's healthcare provider discovers an underlying problem that is causing your child's early signs of puberty, other treatment may be needed.