Supprelin LA and Pregnancy
The FDA has given a pregnancy Category X rating to Supprelin LA (histrelin implant). This means that the drug is considered unsafe for use during pregnancy. Because this medication decreases levels of estrogen (a hormone important for a healthy pregnancy), the risk of fetal problems and miscarriage is increased when a woman uses it during pregnancy.
Can Pregnant Women Use Supprelin LA?Supprelin® LA (histrelin implant) is a prescription hormone medication used in children. It helps to stop puberty in children who are starting puberty earlier than normal. Supprelin LA should not be used in pregnant women, as it may cause miscarriages or other fetal harm.
What Is Pregnancy Category X?The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category X is given to medicines that show problems to the fetus in animal studies or in human use of the medication. With this category, the potential risks clearly outweigh the potential benefits.
Supprelin LA was shown to increase the risk for birth defects when given to pregnant rabbits throughout pregnancy, but not in pregnant rats. In addition, the medication increased the risk for miscarriages when small and large doses were given to pregnant rats and rabbits. The miscarriage risk was higher with the higher doses.
Supprelin LA has not been studied in pregnant women. The medication works by decreasing estrogen levels in women. Because estrogen is necessary for a healthy pregnancy, Supprelin LA is not considered safe for use in women who are pregnant or may become pregnant.
Final ThoughtsSupprelin LA can cause miscarriages or harm a developing baby if used by a pregnant woman. You should not receive this medicine if you are pregnant or may become pregnant during treatment. Therefore, if you are pregnant or thinking about becoming pregnant while using Supprelin LA, talk to your healthcare provider.