Clinical Effects

In clinical studies, PROVENGE was shown to increase survival time when given to men with metastatic, hormone refractory prostate cancer (prostate cancer that has spread beyond the prostate, and is no longer responsive to hormone therapy). In these studies, men given PROVENGE survived an average of four months longer than men given a placebo (an injection that did not contain the active ingredient).

When and How to Use It

Some general considerations to keep in mind during treatment with PROVENGE include the following:
  • This medication is given as an injection into a vein (an intravenous, or IV, injection) approximately every two weeks, for a total of three doses.
  • You will need a procedure to have some white blood cells removed from your blood about three days before each PROVENGE injection. Your white blood cells will be used to create your individual PROVENGE dose.
  • The PROVENGE IV injection is given slowly, over about 60 minutes. A slow IV injection is also sometimes called an IV infusion.
  • Your healthcare provider may give you medications, such as acetaminophen (Tylenol®) and diphenhydramine (Benadryl®, Sominex®, and many others), about 30 minutes before your PROVENGE dose. These "premedications" help reduce the chance of infusion reactions, such as fever and chills.
  • For this drug to work properly, it must be used as prescribed. Make sure to keep all of your appointments with your healthcare provider.

Dosing Information

There is only one standard dose of this medication. Each of your PROVENGE doses will be created specifically for you, using your body's white blood cells, and cannot be used by anyone else.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
(Click PROVENGE Dosage for more information.)
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