Prostate Cancer Home > Vantas Uses

Your healthcare provider may prescribe Vantas to help relieve the symptoms of advanced prostate cancer. This medicine works by decreasing testosterone levels in men, which can slow down the growth rate of prostate cancer cells that need testosterone to grow and multiply. Possible off-label uses of Vantas may include treating other types of cancer, including ovarian and pancreatic cancer.

What Is Vantas Used For?

Vantas® (histrelin implant) is a prescription medication used in the treatment of advanced prostate cancer. It comes as a tiny implant that is inserted under the skin, where it stays in place for an entire year, delivering a continuous amount of medication to the body. After a year, the implant is removed and, if treatment is to continue, a new implant is inserted.
Prostate cancer is considered advanced when it has spread to other parts of the body, such as the bladder, rectum, bone, or other areas. Advanced prostate cancer is also called metastatic prostate cancer. The goal of treatment for advanced prostate cancer is to slow down the growth of the cancer cells and manage the symptoms of the condition. This is called palliative treatment.
Vantas is approved for the palliative treatment of advanced prostate cancer. As a palliative treatment option, Vantas can help ease prostate cancer symptoms, but it will not cure prostate cancer.

How Does This Medicine Work?

Vantas is a synthetic (manufactured) version of gonadotropin-releasing hormone (GnRH), a naturally occurring hormone that controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland (a tiny gland located beneath the brain). LH and FSH stimulate the production of testosterone in the testes.
Vantas works by overstimulating the pituitary gland, so it does not make as much LH and FSH. As a result, the testes stop making testosterone. This causes testosterone levels to decrease. Most forms of prostate cancer are dependent on testosterone to grow. By reducing testosterone levels, Vantas slows down the growth rate of the cancer cells.
The Vantas implant slowly releases medicine into the body over a 12-month period. This allows for once-a-year dosing.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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