Prostate Cancer Home > Flutamide Side Effects

Common Side Effects

Flutamide has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of people taking flutamide were carefully documented and compared to those that occurred in another group of people receiving either a different treatment or a placebo (a "sugar pill" with no active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the other groups.
It should be noted that everyone also received a gonadotropin-releasing hormone (GnRH) agonist in the clinical trials. Therefore, it can be difficult to know for certain which side effects are from flutamide and which are a result of the GnRH agonist.
In clinical studies, the most commonly reported reactions included:
  • Hot flashes -- in up to 61 percent of people
  • Loss of libido (loss of sex drive) -- up to 36 percent
  • Impotence (erectile dysfunction, or ED) -- up to 33 percent
  • Diarrhea -- up to 12 percent
  • Nausea and vomiting -- up to 11 percent
  • Enlarged breasts -- up to 9 percent
  • Gastrointestinal (GI) problems -- up to 6 percent
  • Decrease in red blood cells (anemia) -- up to 6 percent.
Other common side effects (occurring in 1 to percent of people) included:
Flutamide has also been reported to cause urine discoloration. The urine may appear orange-yellow or yellow-green in color.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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