Available in the form of a tablet, Casodex is a medication used to treat prostate cancer that has spread to other areas of the body (advanced metastatic prostate cancer). It is taken once a day and is used in combination with another prostate cancer medication. Most people tolerate it well, but it has been known to cause side effects such as weakness, constipation, and hot flashes.
What Is Casodex?
Casodex® (bicalutamide) is a prescription medication approved for the treatment of advanced metastatic prostate cancer (prostate cancer that has spread to other areas of the body). It is used in combination with another prostate cancer medication that lowers the levels of testosterone in the body.
Casodex is manufactured by IPR Pharmaceuticals, Inc., for AstraZeneca Pharmaceuticals LP. Generic versions are made by various manufacturers.
How Does Casodex Work?
Prostate cancer cells grow in response to androgens (male sex hormones). Casodex is an androgen receptor inhibitor (sometimes called an antiandrogen). It works by binding to androgen receptors in the prostate and blocking the effect of naturally occurring androgens. This helps prevent the growth of cancer cells.
Casodex is used in combination with a gonadotropin-releasing hormone (GnRH) agonist medicine (sometimes called a luteinizing hormone-releasing hormone agonist). GnRH agonists reduce the amount of testosterone made by the body. Casodex blocks the action of the remaining testosterone.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Casodex [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP;2009 November.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed June 23, 2011.
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