Prostate Cancer Home > Casodex Warnings and Precautions

Because Casodex is not suitable for everyone, your healthcare provider needs to know if you have diabetes, anemia, or any other medical conditions before starting treatment. Other precautions for Casodex include warnings of potentially serious side effects, such as liver problems, that may occur during treatment. If you are allergic to any of the ingredients used to make this product, you should not take Casodex.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Casodex® (bicalutamide) if you have:
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Diabetes
  • Anemia or other blood cell problems
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Casodex

Some warnings and precautions to be aware of prior to taking this medication include the following:
  • Casodex has been reported to cause drowsiness. Do not drive, operate heavy machinery, or do anything else that could be dangerous until you know how the medication affects you.
  • This medication is used as part of combination prostate cancer treatment, with a gonadotropin-releasing hormone (GnRH) agonist medication, sometimes called luteinizing hormone-releasing hormone (LH-RH) agonists. Make sure to take both medicines as prescribed. Do not stop either one without talking to your healthcare provider.
  • Taking Casodex in combination with a GnRH agonist can increase the risk of high blood sugar or developing diabetes. Your healthcare provider may monitor you for diabetes during treatment, or if you have diabetes, recommend you check your blood glucose levels more often.
  • Some people may experience a worsening of prostate cancer while taking Casodex. Your healthcare provider will closely monitor your condition during treatment, which may include checking your prostate-specific antigen (PSA) levels. If your cancer progresses and your PSA increases, your healthcare provider may recommend that you stop Casodex.
  • There have been cases of serious liver problems in people taking Casodex. Your healthcare provider will monitor your liver function, using blood tests, before you start this drug and routinely during treatment. Contact your healthcare provider right away if you experience signs of liver problems, including:
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Loss of appetite
    • Nausea and vomiting
    • Stomach pain
    • Fatigue.
  • This product may react with a number of other medications (see Casodex Drug Interactions for more information).
  • Casodex is considered a pregnancy Category X medication. It should not be used in women who are pregnant or who may become pregnant (see Casodex and Pregnancy).
  • It is unknown if this medicine passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to beginning treatment (see Casodex and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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