Lupron Depot Drug Interactions

Medications used to treat diabetes, such as insulin, glitazones, metformin, and sulfonylureas, are the only drugs expected to interact with Lupron Depot. As a result, if you have diabetes and are taking Lupron Depot, your healthcare provider may adjust the doses of your diabetes medications and have you check your blood sugar more often.

• Alpha-glucosidase inhibitors, such as:
   
  • Acarbose (Precose^®)
  • Miglitol (Glyset^®)

• Dipeptidyl peptidase-4 (DPP-4) inhibitors, such as:
   
  • Alogliptin (Nesina^®), alogliptin and metformin (Kazano^®), and alogliptin and pioglitazone (Oseni^®)
  • Linagliptin (Tradjenta™)
  • Linagliptin and metformin (Jentadueto™) 
  • Saxagliptin (Onglyza™)
  • Sitagliptin (Januvia^®)
  • Sitagliptin and metformin (Janumet^®)
  • Sitagliptin and metformin XR (Janumet^® XR)

• Glitazones and glitazone combination medications, such as:
   
  • Pioglitazone hydrochloride (Actos^®)
  • Pioglitazone and glimepiride (Duetact^®)
  • Pioglitazone and metformin (Actoplus Met^®)
  • Pioglitazone and metformin XR (Actoplus Met^® XR)
  • Rosiglitazone (Avandia^®)
  • Rosiglitazone and glimepiride (Avandaryl^®)
  • Rosiglitazone and metformin (Avandamet^®)

• Glucagon-like peptide 1 receptor agonists, such as:
   
  • Exenatide (Byetta^®)
  • Liraglutide (Victoza^®)

• Insulin of any type
• Meglitinides, such as:
   
  • Nateglinide (Starlix^®)
  • Repaglinide (Prandin^®)

• Metformin (Glucophage^®, Glucophage XR^®, Fortamet^®, Glumetza^®, Riomet^®)
• Sulfonylureas or sulfonylurea combination medications, such as:
   
  • Chlorpropamide (Diabinese^®)
  • Glimepiride (Amaryl^®)
  • Glimepiride and pioglitazone (Duetact^®)
  • Glimepiride and rosiglitazone (Avandaryl^®)
  • Glipizide (Glucotrol^®, Glucotrol XL^®)
  • Glipizide and metformin (Metaglip^®)
  • Glyburide (DiaBeta^®, Micronase^®, Glynase^®)
  • Glyburide and metformin (Glucovance^®)
  • Tolazamide (Tolinase^®)
  • Tolbutamide (Orinase^®).