Jevtana and Pregnancy

Jevtana (cabazitaxel) is generally considered unsafe for use during pregnancy. When low doses were given to pregnant rats and rabbits, the medication increased the risk for miscarriages. However, a healthcare provider may still prescribe Jevtana during pregnancy if he or she believes the benefits to the pregnant woman outweigh the risks to the unborn child.

Can I Receive Jevtana When Pregnant?

Jevtana® (cabazitaxel) is a chemotherapy medication approved for the treatment of prostate cancer. As with most chemotherapy drugs, Jevtana may be harmful to a developing fetus.
Although this medication is not approved for use in women -- it is only approved for prostate cancer treatment -- it could be used "off-label" to treat other types of cancer in women.

What Is Pregnancy Category D?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category D is given to medicines that have shown clear evidence of risk to the fetus in studies. Pregnancy Category D is a stronger warning than a pregnancy Category C classification.
Jevtana was given a pregnancy Category D rating because of problems in animal studies. When given to pregnant rats and rabbits, even low doses of Jevtana increased the risk for miscarriages.
It is important to note that animals do not always respond to medicines in the same way that humans do. Therefore, a pregnancy Category D medicine may be given to a pregnant woman if the healthcare provider believes that the benefits to the woman outweigh any possible risks to the unborn child.

Final Thoughts

If you are pregnant or thinking about becoming pregnant, let your healthcare provider know. He or she will consider the benefits and risks of using Jevtana during pregnancy before making a recommendation in your particular situation.
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