Fentanyl Nasal Spray Side Effects

Common Side Effects

Fentanyl nasal spray has been studied extensively in clinical trials. In these studies, the side effects that occurred in people using the nasal spray were carefully documented. All of the people in the studies were taking long-acting opioid narcotics in addition to fentanyl nasal spray. Therefore, it can be difficult to know for certain which side effects resulted from fentanyl nasal spray and which were from the other narcotics.
In clinical studies, common side effects of fentanyl nasal spray included:
  • Vomiting -- in up to 13 percent of people
  • Constipation -- up to 10 percent
  • Nausea -- up to 9 percent
  • Fever -- up to 7 percent
  • Dizziness -- up to 6 percent.
Other common side effects, occurring in at least 1 percent of people, included:
  • Diarrhea
  • Headaches
  • Dry mouth
  • Heartburn or indigestion
  • Abdominal (stomach) pain
  • Drowsiness
  • Fatigue
  • Weakness
  • Decreased appetite and weight loss
  • Shortness of breath
  • Coughing
  • Pain, including pain in the back, arms, legs, and joints
  • Dry eyes
  • Drooping eyelids
  • Crossed eyes
  • Low blood cell counts
  • Mouth ulcers
  • Rectal pain
  • Body swelling, especially of the legs, ankles, and feet
  • Yellowing of the skin or whites of the eyes (jaundice)
  • Altered sense of taste
  • Behavior or mood changes, such as anxiety, depression, confusion, or agitation
  • Insomnia
  • Infection, including urinary tract infections (UTIs) and upper respiratory infections (such as the common cold)
  • Falls
  • Increase in certain liver enzymes
  • Dehydration
  • Increased blood sugar levels
  • Nosebleed
  • Runny nose or nasal congestion
  • Itching
  • Sweating
  • Increased blood pressure (hypertension).
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Fentanyl Nasal Spray Information

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