Fentanyl Nasal Spray for Pain

Available by prescription only, fentanyl nasal spray (Lazanda®) is a medicine prescribed to treat breakthrough cancer pain in people who are already taking around-the-clock pain medicine. It is only approved for use in people who have already been using opioids and who are tolerant to their effects.
When used for treating breakthrough pain, fentanyl nasal spray works by binding to a specific type of opioid receptor located throughout the body, called the opioid mu-receptor.
Fentanyl nasal spray is sprayed into the nostril, where it is absorbed through the inner lining of the nose into the bloodstream. The usual dose is one or two sprays into the nostril no more than four times a day, as needed for pain. Blood levels peak approximately 15 to 20 minutes after the medication is used.
(Click What Is Fentanyl Nasal Spray Used For? for more details on this topic. This article also describes how the drug works and whether there are off-label uses.)
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