Drug Interactions With Fentanyl Nasal Spray

Drug Interactions With Fentanyl Nasal Spray Explained

The following sections explain in detail the potentially negative reactions that can occur when fentanyl nasal spray is combined with any of the drugs listed above.
 
Alcohol
Consuming alcohol while using fentanyl nasal spray could potentially increase your risk for serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. You should not drink alcohol while using this medication.
 
CYP 3A4 Inducer Medications
The liver breaks down fentanyl nasal spray using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining fentanyl nasal spray with one of these CYP 3A4 inducers may decrease the level of fentanyl nasal spray in your bloodstream, potentially making it less effective. Your healthcare provider may need to monitor you more closely if you take fentanyl nasal spray with a CYP 3A4 inducer.
 
CYP 3A4 Inhibitor Medications
The liver breaks down fentanyl nasal spray using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining fentanyl nasal spray with one of these CYP 3A4 inhibitors may increase the level of fentanyl nasal spray in your bloodstream to potentially unsafe levels. Your healthcare provider should monitor you more closely if you take fentanyl nasal spray with a CYP 3A4 inhibitor.
 
Grapefruit Juice
Grapefruit juice may increase the amount of fentanyl nasal spray in your blood, potentially increasing your risk for serious side effects, such as drowsiness, confusion, and breathing problems. Talk to your healthcare provider before eating grapefruit or drinking grapefruit juice while you are using fentanyl nasal spray.
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Fentanyl Nasal Spray Information

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