Drug Interactions With Docetaxel

Several medications can cause drug interactions with docetaxel, including certain antibiotics or antifungals, some seizure medications, and "live" vaccinations. Some of these docetaxel drug interactions can alter the amount of docetaxel in your blood. As a result, you may be at an increased risk of side effects or the medication may not be as effective.

An Overview of Drug Interactions With Docetaxel

Docetaxel (Taxotere®) can potentially interact with other medications. Some of these medicines that may lead to docetaxel interactions include:
 
  • Certain antibiotics or antifungals, including:
o Erythromycin (Ery-Tab®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Miconazole
o Telithromycin (Ketek®)
  • Certain anticonvulsants, including:
o Carbamazepine (Epitol®, Equetro™, Tegretol®, Tegretol XR®)
o Fosphenytoin (Cerebyx®)
o Phenobarbital (Luminal®)
o Pentobarbital (Nembutal®)
  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
  • "Live" vaccinations, including:
o FluMist® (the nasal vaccine for influenza; the injected vaccine is not live)
o MMR vaccine (measles, mumps, rubella vaccine)
o Smallpox vaccine
o BCG vaccine (used in some countries for tuberculosis) 
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®).
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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